We explored how curcumin, a natural compound found in turmeric, can protect heart cells during events like myocardial ischemia/reperfusion injury (I/RI). This type of injury occurs when blood supply returns to the heart after a period of low oxygen, often leading to additional damage to heart tissue.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
Read More
8
Curcumin improves lipid profiles
An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.
We explored the impact of curcumin, a component found in turmeric, on lipid profiles that are crucial for cardiovascular health. Our analysis reviewed 26 systematic reviews and meta-analyses involving 72 randomized controlled trials, focusing on how curcumin supplementation affects levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides in the body.
The findings from our assessment confirmed that curcumin does have an anti-lipidemic effect, meaning it can potentially improve lipid metabolism among patients with noncommunicable diseases. Notably, curcumin with enhanced bioavailability is recommended, and those looking to reap benefits should consider supplementation for at least 8 weeks. Additionally, incorporating exercise during this period can further reduce the risk of atherosclerotic cardiovascular disease.
Overall, we believe that curcumin can be a helpful tool in managing cardiovascular risks, particularly when combined with lifestyle changes. However, it’s important to approach supplementation thoughtfully for the best outcomes.
Read More
8
Inhaled turmerone protects aorta
Inhaled turmerone can attenuate nicotine-induced degeneration of the aorta.
We explored the effects of inhaled turmerone, a compound found in turmeric, on the degeneration of the aorta caused by nicotine. This research is significant because nicotine from secondhand smoke is known to increase the risk of cardiovascular disease. Our study focused on understanding how inhaled turmerone might counteract these harmful effects.
In our investigation, we observed that inhaling turmeric essential oil helped reduce the nicotine-induced damage, specifically protecting the elastic fibers in the aorta and decreasing levels of certain harmful enzymes. We noted that the blood of mice that inhaled the turmeric essential oil contained all three types of turmerone: α-turmerone, β-turmerone, and ar-turmerone. Among these, ar-turmerone emerged as the most effective in protecting the aorta from nicotine damage.
Overall, our findings suggest that inhaling turmerone may indeed help mitigate the negative impacts of nicotine on cardiovascular health, particularly regarding aortic degeneration. This opens up exciting possibilities for using turmeric and its components as a potential protective treatment against the risks associated with nicotine exposure.
Read More
Most Useful Reviews
9
Strong antioxidant properties
I recommend this supplement wholeheartedly, regardless of existing health issues. It is an excellent antioxidant and high-quality product for combating inflammation. The benefits extend to fighting cancer as well. The packaging is commendable; this is suitable for adults of all ages.
Read More
9
Heart health improvement
1 people found this helpful
MY Natural Health Physician states turmeric is renowned for its potent anti-inflammatory effects, vital for managing cardiovascular disease. Studies indicate high doses of curcumin can enhance heart health markers, including lowering LDL cholesterol and fat levels in blood. At 68, I believe curcumin is essential for us. NOW's Phytosome with Meriva Curcumin is excellently formulated for absorption. I highly recommend this product for its value and effectiveness.
Read More
7.5
Improves cognitive functions
Curcumin is acknowledged for its antioxidant and anti-inflammatory benefits. It supports digestive health by reducing inflammation and enhancing bile quality. This supplement may improve daily activities and life quality for those with arthritis, and it also aids in preventing cognitive decline associated with age and cardiovascular disease.
We investigated curcumin, a compound derived from turmeric, and its ability to protect heart cells from damage caused by conditions like myocardial ischemia and reperfusion injury (MIRI). Utilizing a model involving Sprague-Dawley rats and heart cells subjected to anoxia and reoxygenation, we aimed to understand how curcumin affects heart health at a cellular level.
During the experiments, we observed that curcumin significantly reduced MIRI effects. It improved heart tissue structure, increased the viability of heart cells, and inhibited processes related to cell death, specifically ferroptosis, apoptosis, and autophagy. Furthermore, curcumin helped reduce the size of heart tissue damage and preserved overall heart function.
Our findings indicated that MIRI disrupts important protein pathways, leading to cell death by activating autophagy-related genes. However, curcumin appeared to counteract this by activating protective signaling pathways that inhibit these harmful processes. We noted that blocking the action of curcumin nullified its protective effects, underscoring its significance as a heart-protective agent.
Overall, our research supports the idea that curcumin may play a valuable role in safeguarding cardiovascular health, especially under stress conditions like ischemia-reperfusion injury.
Read More
9
Curcumin shows promise for heart health
Preventive and treatment efficiency of dendrosomal nano-curcumin against ISO-induced cardiac fibrosis in mouse model.
We explored the effects of dendrosomal nano-curcumin, a form of curcumin derived from turmeric, on cardiac fibrosis—a major contributor to heart disease. The study utilized both laboratory and animal models to test how well this treatment could counteract damage caused by isoproterenol (ISO), a substance known to induce cardiac fibrosis.
Our observations indicated that when heart cells were treated with ISO to promote fibrosis, the addition of dendrosomal nano-curcumin helped reduce this fibrotic effect. We noted similar positive outcomes in live mouse models where ISO induced heart and lung fibrosis, resulting in the expression of genes linked to inflammation and fibrosis. The application of nano-curcumin before, during, or after ISO treatment showed promise in mitigating these damaging effects.
Furthermore, through advanced RNA sequencing, we identified a gene called COMP that was expressed differently following fibrosis induction, suggesting it could serve as a new marker in understanding heart conditions. Overall, our findings point towards the potential of dendrosomal nano-curcumin as both a preventive and therapeutic agent for heart complications linked to fibrosis.
Read More
9
Curcumin protects heart cells effectively
Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1.
We explored how curcumin, a natural compound found in turmeric, can protect heart cells during events like myocardial ischemia/reperfusion injury (I/RI). This type of injury occurs when blood supply returns to the heart after a period of low oxygen, often leading to additional damage to heart tissue.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
Read More
8
Inhaled turmerone protects aorta
Inhaled turmerone can attenuate nicotine-induced degeneration of the aorta.
We explored the effects of inhaled turmerone, a compound found in turmeric, on the degeneration of the aorta caused by nicotine. This research is significant because nicotine from secondhand smoke is known to increase the risk of cardiovascular disease. Our study focused on understanding how inhaled turmerone might counteract these harmful effects.
In our investigation, we observed that inhaling turmeric essential oil helped reduce the nicotine-induced damage, specifically protecting the elastic fibers in the aorta and decreasing levels of certain harmful enzymes. We noted that the blood of mice that inhaled the turmeric essential oil contained all three types of turmerone: α-turmerone, β-turmerone, and ar-turmerone. Among these, ar-turmerone emerged as the most effective in protecting the aorta from nicotine damage.
Overall, our findings suggest that inhaling turmerone may indeed help mitigate the negative impacts of nicotine on cardiovascular health, particularly regarding aortic degeneration. This opens up exciting possibilities for using turmeric and its components as a potential protective treatment against the risks associated with nicotine exposure.
Read More
8
Curcumin improves lipid profiles
An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.
We explored the impact of curcumin, a component found in turmeric, on lipid profiles that are crucial for cardiovascular health. Our analysis reviewed 26 systematic reviews and meta-analyses involving 72 randomized controlled trials, focusing on how curcumin supplementation affects levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides in the body.
The findings from our assessment confirmed that curcumin does have an anti-lipidemic effect, meaning it can potentially improve lipid metabolism among patients with noncommunicable diseases. Notably, curcumin with enhanced bioavailability is recommended, and those looking to reap benefits should consider supplementation for at least 8 weeks. Additionally, incorporating exercise during this period can further reduce the risk of atherosclerotic cardiovascular disease.
Overall, we believe that curcumin can be a helpful tool in managing cardiovascular risks, particularly when combined with lifestyle changes. However, it’s important to approach supplementation thoughtfully for the best outcomes.
I recommend this supplement wholeheartedly, regardless of existing health issues. It is an excellent antioxidant and high-quality product for combating inflammation. The benefits extend to fighting cancer as well. The packaging is commendable; this is suitable for adults of all ages.
Read More
9
Heart health improvement
1 people found this helpful
MY Natural Health Physician states turmeric is renowned for its potent anti-inflammatory effects, vital for managing cardiovascular disease. Studies indicate high doses of curcumin can enhance heart health markers, including lowering LDL cholesterol and fat levels in blood. At 68, I believe curcumin is essential for us. NOW's Phytosome with Meriva Curcumin is excellently formulated for absorption. I highly recommend this product for its value and effectiveness.
Read More
7.5
Improves cognitive functions
Curcumin is acknowledged for its antioxidant and anti-inflammatory benefits. It supports digestive health by reducing inflammation and enhancing bile quality. This supplement may improve daily activities and life quality for those with arthritis, and it also aids in preventing cognitive decline associated with age and cardiovascular disease.
Read More
7.5
Antioxidant for prevention
Turmeric in phytosomes is effective for various conditions, significantly aiding cardiovascular health and cognitive function while reducing disease risks. It is beneficial for Alzheimer's prevention, arthritis, depression, and may slow the body's ageing process.
Read More
6
Potential anti-cancer
Curcumin has proven anti-inflammatory properties and can assist in chronic inflammatory conditions like ulcerative colitis. It also shows potential in cancer treatment. Furthermore, curcumin may enhance the efficacy of antibiotics against Helicobacter pylori and has antidepressant effects. Overall, it's beneficial for health!
Read More
Frequently Asked Questions
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Turmeric curcumin is a natural compound derived from the root of the turmeric plant (Curcuma longa), a spice commonly used in cooking, particularly within Indian cuisine. Curcumin is the primary active ingredient in turmeric, known for its bright yellow color and various health benefits. It boasts strong anti-inflammatory and antioxidant properties, which have made it popular in both culinary practices and dietary supplements. Many people incorporate turmeric curcumin into their diets in order to support overall health, alleviate joint pain, and bolster immune function.
In recent years, turmeric curcumin has gained attention in the wellness community, leading to the production of numerous supplements that isolate this powerful compound. When considering turmeric curcumin supplements, it's essential to note that curcumin is poorly absorbed by the body on its own, so many products include added black pepper extract (piperine) to enhance absorption. As the potential health benefits and culinary uses of turmeric curcumin continue to be explored, a growing number of consumers are incorporating it into their lifestyles for its perceived benefits. However, as with any supplement, it's advisable to consult with a healthcare professional before starting a new regimen.
A growing body of research suggests that turmeric curcumin may have potential benefits for cardiovascular health. Curcumin, the active compound in turmeric, is known for its antioxidant and anti-inflammatory properties, which could play a role in reducing the risk factors associated with cardiovascular disease. Several studies have indicated that curcumin may help to improve endothelial function, reduce arterial stiffness, and lower levels of harmful cholesterol, all of which are crucial for maintaining a healthy heart and circulatory system.
However, it's important to note that while the preliminary findings are promising, more rigorous human trials are needed to firmly establish the effectiveness of turmeric curcumin for cardiovascular disease prevention and treatment. As always, it's best to consult with a healthcare provider before making any significant changes to your diet or supplementation routine. Incorporating turmeric as part of a balanced diet may be beneficial, but should not be considered a replacement for conventional medical treatment or lifestyle modifications known to support heart health, such as regular exercise and a healthy diet.
Based on user reviews, the timeline for seeing results from the supplement, particularly for cardiovascular disease, varies from person to person. Some users highlight the need for consistency in taking the supplement to truly notice its benefits. One review noted that curcumin's effects on heart health markers, such as lowering LDL cholesterol, can be observed over time, particularly with high doses Read Review.
Users generally report feeling improvements in their overall health and well-being after several weeks of regular use. However, many emphasize that substantial benefits, especially related to chronic conditions, may take longer and require sustained intake for the best results. For example, one reviewer expressed that curcumin aids in preventing cognitive decline and enhancing daily activities, implying that its impact can be cumulative Read Review. While some may notice changes within weeks, a full assessment of its effectiveness could take several months of continued usage.
Curcumin, a key compound found in turmeric, has garnered attention for its potential benefits in cardiovascular health, supported by several scientific studies. Research indicates that curcumin exhibits an anti-lipidemic effect, improving lipid profiles—such as lowering total cholesterol and LDL levels—which are essential for cardiovascular health ([2]). Furthermore, multiple studies have demonstrated its ability to protect heart cells from ischemic damage and other forms of cardiac stress, highlighting its role in promoting cell survival and maintaining heart function under duress ([4]; [8]). These findings suggest a promising avenue for using curcumin as a natural supplement to mitigate risks associated with cardiovascular diseases.
However, while certain studies show curcumin's beneficial effects on risk factors related to heart health, caution is advised as results may not always translate into direct evidence of preventing cardiovascular disease ([3]). For example, while curcumin appears to assist in managing cardiometabolic indicators in women with PCOS, further research is needed to establish direct correlations with cardiovascular disease outcomes ([3]). Overall, the body of evidence points towards the potential of curcumin as a supportive supplement for cardiovascular health, but consumers should approach supplementation with an awareness of the current limitations in the research.
Based on user reviews, many individuals report significant improvements in symptoms related to inflammation, cardiovascular health, and overall well-being after consistent use of the supplement. Users highlight curcumin's remarkable anti-inflammatory properties, which have been found to aid conditions such as arthritis and ulcerative colitis, leading to better daily functioning and a noticeable enhancement in life quality Read Review. Furthermore, some indicate that it may play a role in lowering LDL cholesterol and improving heart health markers, which is particularly beneficial for older adults and those managing cardiovascular diseases Read Review.
Additionally, users share anecdotal evidence suggesting that curcumin can also support cognitive function and possibly aid in the prevention of cognitive decline and Alzheimer's disease. One reviewer emphasized its potential in combating age-related issues and enhancing mental clarity, making it a valuable addition for those concerned about aging Read Review. It is important to note, however, that individual results may vary, and while some experience noticeable changes within weeks, for others, the cumulative benefits unfold over several months of consistent intake.
Users report positive experiences when combining this supplement with other supplements, particularly for managing cardiovascular disease. One review highlights that curcumin, especially in high doses, is renowned for its anti-inflammatory properties, which can significantly improve heart health markers, including lowering LDL cholesterol and fat levels in the blood Read Review. This enhances the effectiveness of other heart-health supplements, making curcumin a strong ally in a comprehensive approach to cardiovascular health.
Moreover, users note that the combination of curcumin with other supplements contributes to an overall improvement in well-being, particularly in managing inflammation and supporting cognitive functions. One reviewer mentions that the anti-inflammatory benefits of curcumin extend to various health issues, including arthritis and digestive health, potentially working synergistically with other treatments to enhance effectiveness Read Review. This suggests that those dealing with multiple chronic conditions could benefit from a well-rounded supplement regimen that includes curcumin.
Users report that turmeric curcumin is widely recognized for its potent anti-inflammatory effects, essential for managing cardiovascular disease. According to one user, their natural health physician noted that studies suggest high doses of curcumin can improve heart health markers, particularly in lowering LDL cholesterol and fat levels in the blood Read Review. The recommendation is clear: for those looking to support their cardiovascular health, incorporating a well-formulated curcumin supplement like NOW's Phytosome with Meriva may be beneficial due to its enhanced absorption properties Read Review.
Furthermore, reviews highlight that curcumin offers a range of additional health benefits, including cognitive function support and reduced inflammation associated with various conditions Read Review. Users also mention that the antioxidant properties of curcumin can contribute to an overall improvement in life quality, particularly for those facing health challenges related to aging and cardiovascular disease Read Review. While specific dosages were not detailed, the consensus among users emphasizes the importance of higher doses of curcumin for optimal health outcomes.
9
Heart health improvement
1 people found this helpful
MY Natural Health Physician states turmeric is renowned for its potent anti-inflammatory effects, vital for managing cardiovascular disease. Studies indicate high doses of curcumin can enhance heart health markers, including lowering LDL cholesterol and fat levels in blood. At 68, I believe curcumin is essential for us. NOW's Phytosome with Meriva Curcumin is excellently formulated for absorption. I highly recommend this product for its value and effectiveness.
7.5
Improves cognitive functions
Curcumin is acknowledged for its antioxidant and anti-inflammatory benefits. It supports digestive health by reducing inflammation and enhancing bile quality. This supplement may improve daily activities and life quality for those with arthritis, and it also aids in preventing cognitive decline associated with age and cardiovascular disease.
7.5
Antioxidant for prevention
Turmeric in phytosomes is effective for various conditions, significantly aiding cardiovascular health and cognitive function while reducing disease risks. It is beneficial for Alzheimer's prevention, arthritis, depression, and may slow the body's ageing process.
8
Curcumin improves lipid profiles
An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.
We explored the impact of curcumin, a component found in turmeric, on lipid profiles that are crucial for cardiovascular health. Our analysis reviewed 26 systematic reviews and meta-analyses involving 72 randomized controlled trials, focusing on how curcumin supplementation affects levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides in the body.
The findings from our assessment confirmed that curcumin does have an anti-lipidemic effect, meaning it can potentially improve lipid metabolism among patients with noncommunicable diseases. Notably, curcumin with enhanced bioavailability is recommended, and those looking to reap benefits should consider supplementation for at least 8 weeks. Additionally, incorporating exercise during this period can further reduce the risk of atherosclerotic cardiovascular disease.
Overall, we believe that curcumin can be a helpful tool in managing cardiovascular risks, particularly when combined with lifestyle changes. However, it’s important to approach supplementation thoughtfully for the best outcomes.
9
Curcumin protects heart cells effectively
Curcumin attenuates myocardial ischemia‑reperfusion‑induced autophagy‑dependent ferroptosis via Sirt1/AKT/FoxO3a signaling.
We investigated curcumin, a compound derived from turmeric, and its ability to protect heart cells from damage caused by conditions like myocardial ischemia and reperfusion injury (MIRI). Utilizing a model involving Sprague-Dawley rats and heart cells subjected to anoxia and reoxygenation, we aimed to understand how curcumin affects heart health at a cellular level.
During the experiments, we observed that curcumin significantly reduced MIRI effects. It improved heart tissue structure, increased the viability of heart cells, and inhibited processes related to cell death, specifically ferroptosis, apoptosis, and autophagy. Furthermore, curcumin helped reduce the size of heart tissue damage and preserved overall heart function.
Our findings indicated that MIRI disrupts important protein pathways, leading to cell death by activating autophagy-related genes. However, curcumin appeared to counteract this by activating protective signaling pathways that inhibit these harmful processes. We noted that blocking the action of curcumin nullified its protective effects, underscoring its significance as a heart-protective agent.
Overall, our research supports the idea that curcumin may play a valuable role in safeguarding cardiovascular health, especially under stress conditions like ischemia-reperfusion injury.
9
Curcumin protects heart cells effectively
Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1.
We explored how curcumin, a natural compound found in turmeric, can protect heart cells during events like myocardial ischemia/reperfusion injury (I/RI). This type of injury occurs when blood supply returns to the heart after a period of low oxygen, often leading to additional damage to heart tissue.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
8
Curcumin improves metabolic markers
Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose-Response Meta-Analysis.
We explored the effects of turmeric, specifically curcumin, on heart health in women suffering from polycystic ovary syndrome (PCOS). Our systematic review analyzed data from several randomized clinical trials, focusing on how curcumin might influence various cardiometabolic risk factors. These include blood sugar levels, insulin resistance, and cholesterol profiles, all of which are essential in assessing cardiovascular health.
The results showed promising effects, revealing that curcumin supplementation led to significant reductions in fasting blood sugar, insulin levels, and total cholesterol in women with PCOS. This suggests that curcumin could potentially play a beneficial role in enhancing cardiometabolic health outcomes.
However, despite these positive findings, we noted that curcumin did not significantly affect body weight or other important hormonal and lipid parameters. Given that the study did not explicitly measure cardiovascular disease outcomes, we remain cautious about claiming direct benefits to heart health solely from curcumin intake.
Overall, our findings indicate that while curcumin may help manage certain metabolic markers in women with PCOS, further research is needed to conclusively link these changes to improvements in cardiovascular disease.
References
Higashihara M, Shimizu D, Kishi C, Sumi T, Kakihara S, et al. Inhaled turmerone can attenuate nicotine-induced degeneration of the aorta. Fitoterapia. 2025;182:106465. doi:10.1016/j.fitote.2025.106465
Unhapipatpong C, Julanon N, Shantavasinkul PC, Polruang N, Numthavaj P, et al. An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles. Nutr Rev. 2025. doi:10.1093/nutrit/nuaf012
Mohammadi S, Ziaei S, Morvaridi M, Hasani M, Mirtaheri E, et al. Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose-Response Meta-Analysis. Health Sci Rep. 2025;8:e70525. doi:10.1002/hsr2.70525
Zhao ST, Qiu ZC, Xu ZQ, Tao ED, Qiu RB, et al. Curcumin attenuates myocardial ischemia‑reperfusion‑induced autophagy‑dependent ferroptosis via Sirt1/AKT/FoxO3a signaling. Int J Mol Med. 2025;55. doi:10.3892/ijmm.2025.5492
Rustichelli S, Lanni C, Zarà M, Guidetti GF, Torti M, et al. Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients. Nutrients. 2024;16. doi:10.3390/nu16244419
Mad Azli AA, Salamt N, Aminuddin A, Roos NAC, Mokhtar MH, et al. The Role of Curcumin in Modulating Vascular Function and Structure during Menopause: A Systematic Review. Biomedicines. 2024;12. doi:10.3390/biomedicines12102281
Beikzadeh B, Khani M, Zarinehzadeh Y, Abedini Bakhshmand E, Sadeghizadeh M, et al. Preventive and treatment efficiency of dendrosomal nano-curcumin against ISO-induced cardiac fibrosis in mouse model. PLoS One. 2024;19:e0311817. doi:10.1371/journal.pone.0311817
Yuan Y, Huang H, Hu T, Zou C, Qiao Y, et al. Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1. Int J Mol Med. 2024;54. doi:10.3892/ijmm.2024.5434